Vaccine Adjuvants Immunological & Clinical Principles

A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses. From the reviews: "This book describes in detail major advances in vaccine adjuvant discovery, design, development, and use. ... fills a void in our knowledge of vaccine adjuvants, providing one authoritative text source for the latest information on this topic. The book meets the authors' objectives superbly. ... it could serve as a reference for students, residents, and practitioners, particularly in the fields of infectious diseases and immunology. ... It will serve as a valuable reference for those interested in this field." (Archana NMI Chatterjee, Doody's Review Service, July, 2006)